知识库文章

How to avoid column splitting in CSV report output with Reporter 3.2

When using a tag for outlier reasons in a CSV report, the tag is placed inside double quotes to prevent the creation of extra columns.

Is there a limitation for the number of custom columns in SCIEX OS Analytics results tables?

In SCIEX OS you can add custom columns via different options. Customized results by using the calculated columns and flagging rules features, normal custom columns added in the results table or the ones added already in a batch. All these are displayed in additional columns.

How to transfer Analyst® data to the network when it is stuck in the Wiff cache backup ?

This procedure explains how to force acquisition files to be transferred to the network when they are stuck in the "WIFF_CACHE_BACKUP" folder (temporary folder).

Diagnosing signal instability when processing data in Analyst®, MultiQuant™, or SCIEX OS software

Signal instability typically results in fluctuating responses from samples with the same level of analytes, causing significant variability in measured outcomes. Due to random fluctuations in peak area, signal instability could also affect linearity and recovery. If signal instability is observed while processing data in Analyst®, MultiQuant, or SCIEX OS software, it's possible to diagnose the source of signal instability by evaluating: 1) sample and material preparation, 2) LCMS method instability, and 3) instrument issues.

Why are scan windows longer than detection windows in a scheduled MRM method in Analyst® software?

When setting up a scheduled MRM (sMRM) method in Analyst® software, users must add the time for the detection window (in seconds). However, sometimes, the resulting scan window for some of the analytes is larger than what is set in the method. Here, the reason for this issue and ways to prevent it are explained.

Purpose of PTD files in project folders in Analyst® software

Files with the PTD (.ptd) extension are database event logs in Analyst® software located within the event log folders in the Analyst Data sub-projects. The event log folders where the PTD files are saved contain the same name as the quantitation methods or results tables from which the event logs are generated. Users can open these files with Notepad, but the information is used internally by the software and is not helpful for end-user purposes.

Turning off the Dynamic Window Extension when using the Scheduled MRM™ algorithm in Analyst® software

The Scheduled MRM™ algorithm is a feature in Analyst® software that includes a dynamic window extension option. This option allows the scan window to be automatically extended up to the duration of the scan window. Using this feature could result in lower dwell time for some analytes and inconsistent scan times between analytes, requiring it to be disabled.

Creating a client license for SCIEX software supported by a concurrent license server

When setting up a concurrent license server for either Analyst® or SCIEX OS software, one of the final steps is to create and distribute the client license - the license installed on the PC where the SCIEX software is installed.

How can I restrict permissions for reporter templates?

It is often necessary that reporter templates are not altered—neither intentionally nor unintentionally. Therefore, it is important to restrict access to the template data files—this can be done at the Windows level in the file properties.

sMRM Calculator in Analyst® shows error 'unable to load method'

sMRM calculator does not work in mixed and integrated mode and displays error 'unable to load method. Check if the method is for the active hardware profile'.

How to Detect Acquisition Method Changes

To detect changes in an acquisition method in Analyst® or Sciex OS, the sample information of two injections can be compared via Microsoft Word to track changes e.g. between runs of separate days.

Change CAD Gas Settings from Simplified (Low, Medium, High) to Operator (0-12) in Analyst® Software

The default setting of CAD gas in Analyst® software is “Simplified” and only allows to adjust CAD gas in three steps (low, medium, high). Switching to “Operator” allows to use values from 0 to 12 which enables a more efficient optimization of this parameter for MS/MS and LIT experiments.

How to check that the heaters located in the source of the MS are working ?

This article describes the procedure to follow to check that the heaters located in the source (Turbo V ion source and IonDrive Turbo V ion source) of the mass spectrometer are working. This procedure describes the procedures for both, Analyst® software and SCIEX OS software.

How to configure stacked injection in SCIEX OS or Analyst® with a Shimadz LC 40

SCIEX OS and Analyst® have a feature that allows you to control the injector of a Shimadz LC chain directly in the Sciex software using custom injection programs. This article describes how to write the program to perform stacked injection with LC 40.