A versatile system capable of taking the lead in quantitative performance.

Introducing the new TripleTOF® 6600+ System

Welcome to an exclusive preview of the next chapter in the TripleTOF® system story. Into the spotlight steps an instrument built and optimized for large-scale quantitative mass spectrometry, refined to deliver accessible, sensitive quantitation robustly using dedicated low flow source technology. Redesigned TOF entrance optics, along with software improvements within the forthcoming Analyst® TF Software 1.8, deliver optimized ion beam control, detector tuning, and scheduled ionization to decrease the risk of downtime over long term usage. Combined with the characteristically fast scanning capability of previous TripleTOF platforms, SWATH® Acquisition, and the ultimate approach for data-independent digital archiving of samples, the instrument you see before you could unlock a world of quantitative data you have never experienced before.

Built for Large-Scale Quantitation and Flexible Use

New source hardware designed to cater to the varied requirements of core and research labs, the TripleTOF® 6600+ delivers both flexible and easy to use low flow ionization for optimal sensitivity and throughput for a given sample set. Combined with the quantitative power of current and future SWATH® Acquistion methods, the TripleTOF® 6600+ system has the performance to deliver sensitive, large scale quantitative data for any application.


Switch seamlessly between analytical, microflow and nanoflow according to the task at hand with OptiFlow® Source and OptiFlow™ Interface.


Redesigned TOF entrance optics, Scheduled Ionization and ion beam control to maximize uptime.

Quantitative Power

Primed for next-generation SWATH® Acquisition for the ultimate data independent acquisition.

Key Features

OptiFlow® Turbo V Source A single source for all low flow applications. SteadySpray™ analytical, micro and nano probes allow the source to deliver flow rates from 200 µL/min down to 100 nL/min, while optimized heater geometry eliminates the need for optimizing spray position.
OptiFlow™ Interface Tool-free switching between flow regimes. OptiFlow™ Interface allows you to easily select the most appropriate flow rate for your experiment without the hassle of breaking vacuum.
TripleTOF® System scan speed Up to 100Hz MS/MS acquisition gives the system unique qualitative and quantitative capabilities, from fast targeted quantitation to highly multiplexed methods. Fast DDA approaches allow more information to be captured from shorter run times, while SWATH® Acquisition, with up to 200 windows per cycle, is capable of producing complete digital records of samples, covering all observable species in a dataset that can be retrospectively mined over and over.
Analyst® TF Software 1.8 New functionality for scheduling ion spray voltages allows the user to control when LC flow is sprayed into the instrument reducing the introduction of potentially contaminating species from your LC. New optimized ion transmission control and detector optimization algorithm give added control over the flux of ions through the instrument to reduce the risk of downtime.
Primed for the evolution of SWATH® Acquisition Variable-window SWATH® Acquisition offers the latest in data independent acquisition, delivering sensitive quantitative data on a large scale across all observable species, allowing the user to create a permanent digital record of their sample that can be interrogated over and over. The TripleTOF® 6600+ system is the platform that will host the next generation of SWATH® Acquisition.

Choose the Right Flow Rate for the Right Job with Optiflow™

Optimum Performance for Microflow Applications

OptiFlow® source and OptiFlow™ interface are built for simple, accessible low flow applications that deliver high sensitivity quantitative and qualitative data. The OptiFlow® Turbo V ion source allows the robust and routine implementation of microflow LC-MS methods for high sensitivity quantitation, large-scale, sensitive metabolite profiling and high throughput proteomics methods using intelligent probe technology and optimized SteadySpray™ micro and analytical flow probes to ensure no optimization of the probe is needed and that a stable spray can be reproducibly achieved time after time.

Easy to Use Nanoflow for Challenging Sample Types

The OptiFlow® Turbo V Source will also uniquely allow the user to switch to nanoflow regimes for highest sensitivity of proteomics samples where sample amount or concentration makes their analysis challenging such as low volume biopsy samples, IP pulldowns or detection of low abundance proteins in a targeted analysis. Using the forthcoming SteadySpray™ nano probes, the OptiFlow® Turbo V Source delivers the high performance nanospray that these sample types demand, with minimal downtime and setup time.

The Right Flow Rate for the Right Job

Choosing the right flow rate to tackle a specific analytical challenge is simple with OptiFlow- switching between low flow regimes no longer requires breaking vacuum, changing source or re-optimisation of source parameters, allowing you to change between the flow rates appropriate for the job at hand without compromise.

OptiFlow™ Interface

Simple, tool-free switching between nanoflow and micro/ analytical flow rates without the need to break vacuum.

OptiFlow® Turbo V Source

OptiFlow® Turbo V Source for TripleTOF 6600+ extends the flexible microflow capabilities of OptiFlow to nanoflow applications.

OptiFlow™ Interface

Routine switching between nano and microflow rates with no compromise in nanospray performance.

Fast Whole Proteome Profiling With Microflow

Deep mining of proteomes that can be achieved overnight. Microflow enables protein identification using a fractionation approach in just 15 hours of acquisition time.

Accelerated Proteomics

Rapid quantitative profiling of up to 100 samples per day using microflow chromatography with variable-windowed SWATH® Acquisition.