How does the SCIEX OS software calculate the IS Quality in the results table ?

For research use only. Not for use in diagnostic procedures.

Answer

If a component has an IS with an integrated peak, then the "IS Quality" value is the ratio of the IS peak area and the sum of the IS peak area and the area around the IS peak.

IS Quality = IS peak area / (IS peak area + Area around IS peak)

In a "no noise" situation, these areas are the same and the IS Quality is 1. An increase in the noise results in a lower value for the IS peak quality. Hence, the maximum value for the IS Quality can be 1 and the minimum value can be 0.

Example of IS Quality value as a function of IS area and background noise :